International Council for Harmonisation (ICH)

Swissmedic is also involved in drafting international guidelines in the framework of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), formerly known as the International Conference on Harmonisation.

Founded in 1990, the ICH aims to make recommendations towards achieving greater harmonisation in the interpretation and application of technical guidelines for the assessment and market authorisation of medicinal products for human use, thereby minimising duplication during development and the authorisation process. Swissmedic represented the EFTA (European Free Trade Association) states on the ICH Steering Committee, the executive body of the ICH, as an observer until the end of June 2014 and as a member of the Steering Committee in its own right since July 2014. Following the reform of the ICH in 2015, Swissmedic became a Standing Regulatory Member of the Management Committee and an Assembly member.

Swissmedic experts also take an active part in various ICH Expert Working Groups dealing with the quality and safety of medicines, preclinical and clinical requirements, and issues regarding the constitution of authorisation dossiers.

Information on implementation of ICH Guidelines by Swissmedic

General principle

According to a publication in the Swissmedic Journal 5/2006, page 504, ICH Guidelines are regarded as harmonised within the ICH process with adoption of step 4 and are considered as “state of the art in science and technology”.

Since 2009, Swissmedic publishes a statement on its website after each ICH meeting. The publication specifies explicitly when an ICH guideline has reached Step 4 (adoption of an ICH harmonised guideline). In general, implementation in Switzerland coincides with the date of Step 4 adoption; exceptions are listed below.

Overview of ICH Guidelines not yet implemented in Switzerland

ICH Guideline

Title

Implementation status

Q12

Lifecycle Management

Full implementation planned with revision of EU pharmaceutical legislation

E2B(R3)

Maintenance of the ICH Guideline in Clinical Safety Data Management: Data Elements for the Transmission of ICSRs

Current system is based on E2B (R2)

E19

Safety Data Collection

Full implementation foreseen with revision of the ClinO

M4(R4)

Common Technical Document

Full implementation with eCTDv4; see M8

M8 eCTD v4.0

Electronic Common Technical Document (eCTD v4.0)

Full implementation with eCTDv4

Public Consultation

Comments can be provided in English using the feedback form specified by ICH (ICH Template) to networking@swissmedic.ch. Comments that are submitted will be forwarded to the ICH Secretariat. Stakeholders will receive confirmation of receipt of their comments but no feedback on the individual comments. After completion of the public consultation phase, the comments submitted will be discussed in the responsible ICH working groups and taken into account where appropriate.

Supplementary information

Last modification 09.09.2024

Top of page